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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
9.39
Human Site:
S537
Identified Species:
14.76
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
S537
L
T
T
I
D
K
V
S
G
K
R
V
V
N
P
Chimpanzee
Pan troglodytes
XP_524527
588
65774
S537
L
T
T
I
D
K
V
S
G
K
R
V
V
N
P
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
S537
L
T
T
I
D
K
V
S
G
K
R
I
V
N
P
Dog
Lupus familis
XP_537131
637
71340
G587
L
T
I
E
K
V
S
G
K
R
V
V
N
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
G536
L
T
M
D
K
V
P
G
K
R
V
V
N
P
T
Rat
Rattus norvegicus
Q4V8A3
586
65492
G536
L
T
T
D
K
V
S
G
K
R
V
V
N
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
A496
P
T
A
D
K
P
V
A
R
R
A
P
E
T
T
Chicken
Gallus gallus
Q5ZIU3
526
59419
A475
P
T
G
E
K
A
S
A
K
R
I
T
E
S
T
Frog
Xenopus laevis
NP_001088793
567
63329
G517
S
V
T
E
K
S
S
G
K
R
I
T
S
Q
T
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
V528
A
P
G
G
E
K
T
V
L
P
K
R
I
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
G604
P
S
S
S
S
G
C
G
G
V
S
G
L
C
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
A766
P
E
T
R
M
T
P
A
Q
A
L
K
H
K
W
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
L510
H
S
W
L
R
R
R
L
P
K
P
P
A
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
L420
A
G
D
L
I
D
L
L
Q
G
L
L
R
Y
D
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
S719
E
W
F
P
P
G
S
S
L
P
G
P
S
E
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
93.3
20
N.A.
20
26.6
N.A.
13.3
6.6
6.6
6.6
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
26.6
33.3
N.A.
26.6
26.6
13.3
33.3
N.A.
26.6
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
7
0
0
7
0
20
0
7
7
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
7
20
20
7
0
0
0
0
0
0
0
7
7
% D
% Glu:
7
7
0
20
7
0
0
0
0
0
0
0
14
7
7
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
14
7
0
14
0
34
27
7
7
7
0
0
7
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
7
20
7
0
0
0
0
0
14
7
7
0
0
% I
% Lys:
0
0
0
0
40
27
0
0
34
27
7
7
0
7
7
% K
% Leu:
40
0
0
14
0
0
7
14
14
0
14
7
7
0
0
% L
% Met:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
20
20
0
% N
% Pro:
27
7
0
7
7
7
14
0
7
14
7
20
0
20
20
% P
% Gln:
0
0
0
0
0
0
0
0
14
0
0
0
0
7
0
% Q
% Arg:
0
0
0
7
7
7
7
0
7
40
20
7
7
0
0
% R
% Ser:
7
14
7
7
7
7
34
27
0
0
7
0
14
14
7
% S
% Thr:
0
54
40
0
0
7
7
0
0
0
0
14
0
7
34
% T
% Val:
0
7
0
0
0
20
27
7
0
7
20
34
20
0
0
% V
% Trp:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _